Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

The enzymatic processing of cellular RNA molecules requires selective recognition of unique chemical and topological features. The unusual 2′,5′-phosphodiester linkages in RNA lariats produced by the spliceosome must be hydrolyzed by the intron debranching enzyme (Dbr1) before they can be metabolize...

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Autors principals: Montemayor, Eric J., Katolik, Adam, Clark, Nathaniel E., Taylor, Alexander B., Schuermann, Jonathan P., Combs, D. Joshua, Johnsson, Richard, Holloway, Stephen P., Stevens, Scott W., Damha, Masad J., Hart, P. John
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176325/
https://ncbi.nlm.nih.gov/pubmed/25123664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku725
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