Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

The enzymatic processing of cellular RNA molecules requires selective recognition of unique chemical and topological features. The unusual 2′,5′-phosphodiester linkages in RNA lariats produced by the spliceosome must be hydrolyzed by the intron debranching enzyme (Dbr1) before they can be metabolize...

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Bibliographic Details
Main Authors: Montemayor, Eric J., Katolik, Adam, Clark, Nathaniel E., Taylor, Alexander B., Schuermann, Jonathan P., Combs, D. Joshua, Johnsson, Richard, Holloway, Stephen P., Stevens, Scott W., Damha, Masad J., Hart, P. John
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176325/
https://ncbi.nlm.nih.gov/pubmed/25123664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku725
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