Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21(Cip1) Repression

Although previous studies demonstrate that appropriate Notch signaling is required during angiogenesis and in vascular homeostasis, the mechanisms by which Notch regulates vascular function remain to be elucidated. Here, we show that activation of the Notch pathway by the ligand Jagged1 reduces the...

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Main Authors: Noseda, Michela, Chang, Linda, McLean, Graeme, Grim, Jonathan E., Clurman, Bruce E., Smith, Laura L., Karsan, Aly
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC517869/
https://ncbi.nlm.nih.gov/pubmed/15456857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.8813-8822.2004
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