Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis

Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both tumor-suppressor and oncogenic components. In this study we investigated the effects of reactive oxygen species (ROS) on Notch1 signaling outcome in keratinocyte biology. We demonstrate that Notch1 function co...

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Bibliografiske detaljer
Main Authors: Cialfi, Samantha, Palermo, Rocco, Manca, Sonia, De Blasio, Carlo, Vargas Romero, Paula, Checquolo, Saula, Bellavia, Diana, Uccelletti, Daniela, Saliola, Michele, D'Alessandro, Angelo, Zolla, Lello, Gulino, Alberto, Screpanti, Isabella, Talora, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111696/
https://ncbi.nlm.nih.gov/pubmed/24801890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29079
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