PLK1 targets NOTCH1 during DNA damage and mitotic progression

Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both tumor suppressor and oncogenic components. To identify regulators that might control this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-like kinase 1 (PLK1) as o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: De Blasio, Carlo, Zonfrilli, Azzurra, Franchitto, Matteo, Mariano, Germano, Cialfi, Samantha, Verma, Nagendra, Checquolo, Saula, Bellavia, Diana, Palermo, Rocco, Benelli, Dario, Screpanti, Isabella, Talora, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879332/
https://ncbi.nlm.nih.gov/pubmed/31597699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009881
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