The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease

Mutation of the Golgi Ca(2+)-ATPase ATP2C1 is associated with deregulated calcium homeostasis and altered skin function. ATP2C1 mutations have been identified as having a causative role in Hailey-Hailey disease, an autosomal-dominant skin disorder. Here, we identified ATP2C1 as a crucial regulator o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cialfi, Samantha, Le Pera, Loredana, De Blasio, Carlo, Mariano, Germano, Palermo, Rocco, Zonfrilli, Azzurra, Uccelletti, Daniela, Palleschi, Claudio, Biolcati, Gianfranco, Barbieri, Luca, Screpanti, Isabella, Talora, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985699/
https://ncbi.nlm.nih.gov/pubmed/27528123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31567
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