Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma

Notch and basic helix–loop–helix E2A pathways specify cell fate and regulate neoplastic transformation in a variety of cell types. Whereas Notch enhances tumorigenesis, E2A suppresses it. However, whether and how Notch and E2A interact functionally in an integrative mechanism for regulating neoplast...

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Detalhes bibliográficos
Main Authors: Talora, Claudio, Campese, Antonio F., Bellavia, Diana, Pascucci, Monica, Checquolo, Saula, Groppioni, Manuela, Frati, Luigi, von Boehmer, Harald, Gulino, Alberto, Screpanti, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326383/
https://ncbi.nlm.nih.gov/pubmed/14566327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400013
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