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Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TCR) signaling. We demonstrate the occurrence o...

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Autors principals: Bellavia, Diana, Mecarozzi, Marco, Campese, Antonio F, Grazioli, Paola, Talora, Claudio, Frati, Luigi, Gulino, Alberto, Screpanti, Isabella
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829386/
https://ncbi.nlm.nih.gov/pubmed/17332745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601626
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