Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice

The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4(–)8(–) thymocytes and is down-regulated across the CD4(–)8(–) to CD4(+)8(+) transition, controlled by pre-T-cell receptor signaling. To determine the eff...

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Main Authors: Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, Stoppacciaro, Antonella, Tiveron, Cecilia, Tatangelo, Laura, Giovarelli, Mirella, Gaetano, Carlo, Ruco, Luigi, Hoffman, Eric S., Hayday, Adrian C., Lendahl, Urban, Frati, Luigi, Gulino, Alberto, Screpanti, Isabella
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC313949/
https://ncbi.nlm.nih.gov/pubmed/10880446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.13.3337
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