Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice

The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4(–)8(–) thymocytes and is down-regulated across the CD4(–)8(–) to CD4(+)8(+) transition, controlled by pre-T-cell receptor signaling. To determine the eff...

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Autores principales: Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, Stoppacciaro, Antonella, Tiveron, Cecilia, Tatangelo, Laura, Giovarelli, Mirella, Gaetano, Carlo, Ruco, Luigi, Hoffman, Eric S., Hayday, Adrian C., Lendahl, Urban, Frati, Luigi, Gulino, Alberto, Screpanti, Isabella
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2000
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC313949/
https://ncbi.nlm.nih.gov/pubmed/10880446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.13.3337
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