Functional cooperation between ASK1 and p21(Waf1/Cip1) in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Both CDKN1A (p21 (Waf1/Cip1)) and Apoptosis signal-regulating kinase 1 (ASK1) play important roles in tumorigenesis. The role of p21 (Waf1/Cip1) in attenuating ASK1-induced apoptosis by various stress conditions is well established. However, how ASK1 and p21 (Waf1/Cip1) functionally interact during...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: De Blasio, Carlo, Verma, Nagendra, Moretti, Marta, Cialfi, Samantha, Zonfrilli, Azzurra, Franchitto, Matteo, Truglio, Federica, De Smaele, Enrico, Ichijo, Hidenori, Naguro, Isao, Screpanti, Isabella, Talora, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042117/
https://ncbi.nlm.nih.gov/pubmed/33846306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00459-3
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