The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H(3) Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice

Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer’s disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and cholinergic pathways, to create a synergistic effect...

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Publicat a:Front Pharmacol
Autors principals: Sors, Aurore, Krazem, Ali, Kehr, Jan, Yoshitake, Takashi, Dominguez, Gaelle, Henkous, Nadia, Letondor, Claire, Mocaer, Elisabeth, Béracochéa, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177663/
https://ncbi.nlm.nih.gov/pubmed/28066242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00492
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