The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H(3) Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice

Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer’s disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and cholinergic pathways, to create a synergistic effect...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Sors, Aurore, Krazem, Ali, Kehr, Jan, Yoshitake, Takashi, Dominguez, Gaelle, Henkous, Nadia, Letondor, Claire, Mocaer, Elisabeth, Béracochéa, Daniel J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2016
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177663/
https://ncbi.nlm.nih.gov/pubmed/28066242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00492
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