The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H(3) Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice

Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer’s disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and cholinergic pathways, to create a synergistic effect...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Sors, Aurore, Krazem, Ali, Kehr, Jan, Yoshitake, Takashi, Dominguez, Gaelle, Henkous, Nadia, Letondor, Claire, Mocaer, Elisabeth, Béracochéa, Daniel J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2016
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177663/
https://ncbi.nlm.nih.gov/pubmed/28066242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00492
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