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Identification of 1,2,3-triazole derivatives that protect pancreatic β cells against endoplasmmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression
The C/EBP-homologous protein (CHOP) acts as a mediator of endoplasmic reticulum (ER) stress-induced pancreatic insulin-producing β cell death, a key element in the pathogenesis of diabetes. Chemicals that inhibit the expression of CHOP might therefore protect β cells from ER stress-induced apoptosis...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5176337/ https://ncbi.nlm.nih.gov/pubmed/27157393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.03.057 |
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