Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

PURPOSE: Tissue fibrosis caused by pathological activation of fibroblasts with increased synthesis of extracellular matrix components is a major hallmark of systemic sclerosis (SSc). Notch signalling regulates tissue differentiation and pathologic activation of Notch signaling has been implicated in...

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Vydáno v:Arthritis Rheum
Hlavní autoři: Dees, Clara, Zerr, Pawel, Tomcik, Michal, Beyer, Christian, Horn, Angelika, Akhmetshina, Alfiya, Palumbo, Katrin, Reich, Nicole, Zwerina, Jochen, Sticherling, Michael, Mattson, Mark P., Distler, Oliver, Schett, Georg, Distler, Jörg H.W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175482/
https://ncbi.nlm.nih.gov/pubmed/21312186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30254
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