Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here we demonstrate a novel link between transforming growth factor-β and the canonical Wnt pathway. TGF-β stimulate...

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Main Authors: Akhmetshina, Alfiya, Palumbo, Katrin, Dees, Clara, Bergmann, Christina, Venalis, Paulius, Zerr, Pawel, Horn, Angelika, Kireva, Trayana, Beyer, Christian, Zwerina, Jochen, Schneider, Holm, Sadowski, Anika, Riener, Marc-Oliver, MacDougald, Ormond A., Distler, Oliver, Schett, Georg, Distler, Jörg H.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316881/
https://ncbi.nlm.nih.gov/pubmed/22415826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1734
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