Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA

BACKGROUND: Although next generation sequencing (NGS) offers the potential for studying virus populations in unprecedented depth, PCR error, amplification bias and recombination during library construction have limited its use to population sequencing and measurements of unlinked allele frequencies....

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Publicat a:Retrovirology
Autors principals: Boltz, Valerie F., Rausch, Jason, Shao, Wei, Hattori, Junko, Luke, Brian, Maldarelli, Frank, Mellors, John W., Kearney, Mary F., Coffin, John M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175307/
https://ncbi.nlm.nih.gov/pubmed/27998286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0321-6
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