Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA

BACKGROUND: Although next generation sequencing (NGS) offers the potential for studying virus populations in unprecedented depth, PCR error, amplification bias and recombination during library construction have limited its use to population sequencing and measurements of unlinked allele frequencies....

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Bibliographische Detailangaben
Veröffentlicht in:Retrovirology
Hauptverfasser: Boltz, Valerie F., Rausch, Jason, Shao, Wei, Hattori, Junko, Luke, Brian, Maldarelli, Frank, Mellors, John W., Kearney, Mary F., Coffin, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175307/
https://ncbi.nlm.nih.gov/pubmed/27998286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0321-6
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