Ultrasensitive Allele-Specific PCR Reveals Rare Preexisting Drug-Resistant Variants and a Large Replicating Virus Population in Macaques Infected with a Simian Immunodeficiency Virus Containing Human Immunodeficiency Virus Reverse Transcriptase

It has been proposed that most drug-resistant mutants, resulting from a single-nucleotide change, exist at low frequency in human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) populations in vivo prior to the initiation of antiretroviral therapy (ART). To test this hy...

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Bibliographic Details
Main Authors: Boltz, Valerie F., Ambrose, Zandrea, Kearney, Mary F., Shao, Wei, KewalRamani, Vineet N., Maldarelli, Frank, Mellors, John W., Coffin, John M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497681/
https://ncbi.nlm.nih.gov/pubmed/22933296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01963-12
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