Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase η

The environmental pollutant 3-nitrobenzanthrone produces bulky aminobenzanthrone (ABA) DNA adducts with both guanine and adenine nucleobases. A major product occurs at the C8 position of guanine (C8-dG-ABA). These adducts present a strong block to replicative polymerases but, remarkably, can be bypa...

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Publicado no:Chembiochem
Main Authors: Patra, Amritraj, Politica, Dustin A., Chatterjee, Arindom, Tokarsky, E. John, Suo, Zucai, Basu, Ashis K., Stone, Michael P., Egli, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5172388/
https://ncbi.nlm.nih.gov/pubmed/27556902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600420
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