Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Perforin lyses cells by binding to the target cell membrane, where it polymerizes into large nonspecific pores. It is shown here that the first 34 amino acids of the N-terminal region of either human or murine perforin are soluble in aqueous medium and spontaneously insert into membranes. The N-term...

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Hlavní autoři: Ojcius, D M, Persechini, P M, Zheng, L M, Notaroberto, P C, Adeodato, S C, Young, J D
Médium: Artigo
Jazyk:Inglês
Vydáno: 1991
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC51717/
https://ncbi.nlm.nih.gov/pubmed/1711204
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