Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Perforin lyses cells by binding to the target cell membrane, where it polymerizes into large nonspecific pores. It is shown here that the first 34 amino acids of the N-terminal region of either human or murine perforin are soluble in aqueous medium and spontaneously insert into membranes. The N-term...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ojcius, D M, Persechini, P M, Zheng, L M, Notaroberto, P C, Adeodato, S C, Young, J D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51717/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1711204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4621
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!