Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Perforin lyses cells by binding to the target cell membrane, where it polymerizes into large nonspecific pores. It is shown here that the first 34 amino acids of the N-terminal region of either human or murine perforin are soluble in aqueous medium and spontaneously insert into membranes. The N-term...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ojcius, D M, Persechini, P M, Zheng, L M, Notaroberto, P C, Adeodato, S C, Young, J D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51717/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1711204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4621
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