A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Pancreatic islet transplantation is a promising potential cure for type 1 diabetes (T1D). Islet allografts can survive long term in the liver parenchyma. Here we show that liver NK1.1(+) cells induce allograft tolerance in a T1D mouse model. The tolerogenic effects of NK1.1(+) cells are mediated thr...

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Publicado no:Nat Commun
Main Authors: Tripathi, Deepak, Venkatasubramanian, Sambasivan, Cheekatla, Satyanarayana S., Paidipally, Padmaja, Welch, Elwyn, Tvinnereim, Amy R., Vankayalapati, Ramakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171644/
https://ncbi.nlm.nih.gov/pubmed/27982034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13896
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