A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis

In this study, we found that a subpopulation of CD4(+)CD25(+) (85% Foxp3(+)) cells from persons with latent tuberculosis infection (LTBI) inhibits growth of M. tuberculosis (M. tb) in human monocyte-derived macrophages (MDMs). A soluble factor, Rho GDP dissociation inhibitor (D4GDI), produced by apo...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Venkatasubramanian, Sambasivan, Dhiman, Rohan, Paidipally, Padmaja, Cheekatla, Satyanarayana S., Tripathi, Deepak, Welch, Elwyn, Tvinnereim, Amy R., Jones, Brenda, Theodorescu, Dan, Barnes, Peter F., Vankayalapati, Ramakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450061/
https://ncbi.nlm.nih.gov/pubmed/25659138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004617
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