c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice

CD4+CD25+FoxP3+ cells (Tregs) inhibit inflammatory immune responses to allografts. Here, we found that co-transplantation of allogeneic pancreatic islets with Tregs that are defective in c-Jun N-terminal kinase 1 (JNK1) signaling prolongs islet allograft survival in the liver parenchyma of chemicall...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Tripathi, Deepak, Cheekatla, Satyanarayana S., Paidipally, Padmaja, Radhakrishnan, Rajesh Kumar, Welch, Elwyn, Thandi, Ramya Sivangala, Tvinnereim, Amy R., Vankayalapati, Ramakrishna
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818514/
https://ncbi.nlm.nih.gov/pubmed/29459675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21477-9
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