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A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
Pancreatic islet transplantation is a promising potential cure for type 1 diabetes (T1D). Islet allografts can survive long term in the liver parenchyma. Here we show that liver NK1.1(+) cells induce allograft tolerance in a T1D mouse model. The tolerogenic effects of NK1.1(+) cells are mediated thr...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5171644/ https://ncbi.nlm.nih.gov/pubmed/27982034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13896 |
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