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PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA

BACKGROUND: The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. As cccDNA is the transcription template for HBV genomes, it needs to be eliminated from hepatocytes if th...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Retrovirology
Autori principali: Suspène, Rodolphe, Thiers, Valérie, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5168874/
https://ncbi.nlm.nih.gov/pubmed/27998270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0318-1
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