Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage

Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidine deaminases can initiate catabolism of cytoplasmic mitochon...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Suspène, Rodolphe, Mussil, Bianka, Laude, Hélène, Caval, Vincent, Berry, Noémie, Bouzidi, Mohamed S., Thiers, Valérie, Wain-Hobson, Simon, Vartanian, Jean-Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389686/
https://ncbi.nlm.nih.gov/pubmed/28100701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx001
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