Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

The objectives of this study were to prepare bosentan hydrate (BST) microparticles as dry powder inhalations (DPIs) via spray drying and jet milling under various parameters, to comprehensively characterize the physicochemical properties of the BST hydrate microparticles, and to evaluate the aerosol...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lee, Hyo-Jung, Kang, Ji-Hyun, Lee, Hong-Goo, Kim, Dong-Wook, Rhee, Yun-Seok, Kim, Ju-Young, Park, Eun-Seok, Park, Chun-Woong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167478/
https://ncbi.nlm.nih.gov/pubmed/28008226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S120356
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