Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

The objectives of this study were to prepare bosentan hydrate (BST) microparticles as dry powder inhalations (DPIs) via spray drying and jet milling under various parameters, to comprehensively characterize the physicochemical properties of the BST hydrate microparticles, and to evaluate the aerosol...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Lee, Hyo-Jung, Kang, Ji-Hyun, Lee, Hong-Goo, Kim, Dong-Wook, Rhee, Yun-Seok, Kim, Ju-Young, Park, Eun-Seok, Park, Chun-Woong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167478/
https://ncbi.nlm.nih.gov/pubmed/28008226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S120356
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