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Correlations between surface composition and aerosolization of jet-milled dry powder inhaler formulations with pharmaceutical lubricants

Co-jet-milling drugs and lubricants may enable simultaneous particle size reduction and surface coating to achieve satisfactory aerosolization performance. This study aims to establish the relationship between surface lubricant coverage and aerosolization behavior of a model drug (ciprofloxacin HCl)...

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Publicat a:Int J Pharm
Autors principals: Mangal, Sharad, Park, Heejun, Nour, Reham, Shetty, Nivedita, Cavallaro, Alex, Zemlyanov, Dmitry, Thalberg, Kyrre, Puri, Vibha, Nicholas, Mark, Narang, Ajit S., Zhou, Qi (Tony)
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708472/
https://ncbi.nlm.nih.gov/pubmed/31299339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2019.118504
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