Understanding the impacts of surface compositions on the in-vitro dissolution and aerosolization of co-spray-dried composite powder formulations for inhalation

PURPOSE: Dissolution behavior of dry powder inhaler (DPI) antibiotic formulations in the airways may affect their efficacy especially for poorly-soluble antibiotics such as azithromycin. The main objective of this study was to understand the effects of surface composition on the dissolution of spray...

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Pubblicato in:Pharm Res
Autori principali: Mangal, Sharad, Xu, Rongkun, Park, Heejun, Zemlyanov, Dmitry, Shetty, Nivedita, Lin, Yu-Wei, Morton, David, Chan, Hak-Kim, Li, Jian, Zhou, Qi (Tony)
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320342/
https://ncbi.nlm.nih.gov/pubmed/30406281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2527-x
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