Surface composition and aerosolization stability of an inhalable combinational powder formulation spray dried using a three-fluid nozzle

PURPOSE: This study aims to understand the impact of spray drying nozzles on particle surface composition and aerosol stability. METHODS: The combination formulations of colistin and azithromycin were formulated by 2-fluid nozzle (2N) or 3-fluid (3N) spray drying in a molar ratio of 1:1. A 3-factor,...

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Published in:Pharm Res
Main Authors: Shetty, Nivedita, Zhang, Yiwen, Park, Heejun, Zemlyanov, Dmitry, Shah, Dishan, He, Athena, Ahn, Patricia, Mutukuri, Tarun Tejasvi, Chan, Hak-Kim, Zhou, Qi (Tony)
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647382/
https://ncbi.nlm.nih.gov/pubmed/33037471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02937-2
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