Inhibition of p63 Transcriptional Activity by p14(ARF): Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts with and inhibits the ubiquitin ligase MDM2, resulting in p53 stabilization and activation. Once stabilized and activated, p53...

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Bibliografski detalji
Glavni autori: Calabrò, Viola, Mansueto, Gelsomina, Santoro, Raffaela, Gentilella, Antonio, Pollice, Alessandra, Ghioni, Pamela, Guerrini, Luisa, La Mantia, Girolama
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Gene Expression
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC516740/
https://ncbi.nlm.nih.gov/pubmed/15367673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8529-8540.2004
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