Inhibition of p63 Transcriptional Activity by p14(ARF): Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts with and inhibits the ubiquitin ligase MDM2, resulting in p53 stabilization and activation. Once stabilized and activated, p53...

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Detalhes bibliográficos
Main Authors: Calabrò, Viola, Mansueto, Gelsomina, Santoro, Raffaela, Gentilella, Antonio, Pollice, Alessandra, Ghioni, Pamela, Guerrini, Luisa, La Mantia, Girolama
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516740/
https://ncbi.nlm.nih.gov/pubmed/15367673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8529-8540.2004
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