MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells

We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MDM2 overexpression in various cancer cell lines causes p14ARF reduction inducing its degradation through the proteasome. The effect does not require the ubiquitin ligase activity of MDM2 and preferenti...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Vivo, Maria, Matarese, Maria, Sepe, Maria, Di Martino, Rosaria, Festa, Luisa, Calabrò, Viola, Mantia, Girolama La, Pollice, Alessandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344200/
https://ncbi.nlm.nih.gov/pubmed/25723571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117252
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