MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells

We here show a new relationship between the human p14ARF oncosuppressor and the MDM2 oncoprotein. MDM2 overexpression in various cancer cell lines causes p14ARF reduction inducing its degradation through the proteasome. The effect does not require the ubiquitin ligase activity of MDM2 and preferenti...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Vivo, Maria, Matarese, Maria, Sepe, Maria, Di Martino, Rosaria, Festa, Luisa, Calabrò, Viola, Mantia, Girolama La, Pollice, Alessandra
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344200/
https://ncbi.nlm.nih.gov/pubmed/25723571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117252
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