LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining

The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination. Loss of UNC-84 leads to defects in the loading and disassembly of the recombinase RAD-51. Similar to...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Lawrence, Katherine S., Tapley, Erin C., Cruz, Victor E., Li, Qianyan, Aung, Kayla, Hart, Kevin C., Schwartz, Thomas U., Starr, Daniel A., Engebrecht, JoAnne
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166498/
https://ncbi.nlm.nih.gov/pubmed/27956467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604112
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