Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability

Common fragile sites are specific loci that form gaps and constrictions on metaphase chromosomes exposed to replication stress, which slows DNA replication. These sites have a role in chromosomal rearrangements in tumors; however, the molecular mechanism of their expression is unclear. Here we show...

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Detalhes bibliográficos
Main Authors: Schwartz, Michal, Zlotorynski, Eitan, Goldberg, Michal, Ozeri, Efrat, Rahat, Ayelet, Sage, Carlos le, Chen, Benjamin P.C., Chen, David J., Agami, Reuven, Kerem, Batsheva
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283964/
https://ncbi.nlm.nih.gov/pubmed/16291645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340905
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