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Anticorrelated motions as a driving force in enzyme catalysis: The dehydrogenase reaction
Molecular dynamics and cross-correlation analysis of the horse liver alcohol dehydrogenase HLADH·NAD(+)·PhCH(2)O(–) complex has established anticorrelated motions between the NAD(+)-binding domain and other portions of the enzyme. Four pairs of anticorrelated interactions are (i and ii) cofactor-bin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516540/ https://ncbi.nlm.nih.gov/pubmed/15331786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405502101 |
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