Expression Cloning and Production of Human Heavy-Chain-Only Antibodies from Murine Transgenic Plasma Cells

Several technologies have been developed to isolate human antibodies against different target antigens as a source of potential therapeutics, including hybridoma technology, phage and yeast display systems. For conventional antibodies, this involves either random pairing of VH and variable light (VL...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Drabek, Dubravka, Janssens, Rick, de Boer, Ernie, Rademaker, Rik, Kloess, Johannes, Skehel, John, Grosveld, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165034/
https://ncbi.nlm.nih.gov/pubmed/28066429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00619
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