Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. Th...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Xu, Shu, Yang, Hong, Zhuo, Yue, Yu, Yangsheng, Liao, Hongyan, Li, Song, Yue, Yinshi, Su, Kaihong, Zhang, Zhixin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214812/
https://ncbi.nlm.nih.gov/pubmed/32431693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00632
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