Generation of heavy-chain-only antibodies in mice

We have generated transgenic mice containing hybrid llama/human antibody loci that contain two llama variable regions and the human D, J, and Cμ and/or Cγ constant regions. Such loci rearrange productively and rescue B cell development efficiently without LC rearrangement. Heavy-chain-only antibodie...

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Main Authors: Janssens, Rick, Dekker, Sylvia, Hendriks, Rudi W., Panayotou, George, van Remoortere, Alexandra, San, John Kong-a, Grosveld, Frank, Drabek, Dubravka
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2006
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586177/
https://ncbi.nlm.nih.gov/pubmed/17015837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601108103
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