Generation of heavy-chain-only antibodies in mice

We have generated transgenic mice containing hybrid llama/human antibody loci that contain two llama variable regions and the human D, J, and Cμ and/or Cγ constant regions. Such loci rearrange productively and rescue B cell development efficiently without LC rearrangement. Heavy-chain-only antibodie...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Janssens, Rick, Dekker, Sylvia, Hendriks, Rudi W., Panayotou, George, van Remoortere, Alexandra, San, John Kong-a, Grosveld, Frank, Drabek, Dubravka
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586177/
https://ncbi.nlm.nih.gov/pubmed/17015837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601108103
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados