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Generation of heavy-chain-only antibodies in mice
We have generated transgenic mice containing hybrid llama/human antibody loci that contain two llama variable regions and the human D, J, and Cμ and/or Cγ constant regions. Such loci rearrange productively and rescue B cell development efficiently without LC rearrangement. Heavy-chain-only antibodie...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1586177/ https://ncbi.nlm.nih.gov/pubmed/17015837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601108103 |
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