Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice

In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum. Camelids are an exception, expressing homodimeric IgGs, an antibody type that to date has not been found...

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Detalhes bibliográficos
Main Authors: Zou, Xiangang, Osborn, Michael J., Bolland, Daniel J., Smith, Jennifer A., Corcos, Daniel, Hamon, Maureen, Oxley, David, Hutchings, Amanda, Morgan, Geoff, Santos, Fatima, Kilshaw, Peter J., Taussig, Michael J., Corcoran, Anne E., Brüggemann, Marianne
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150980/
https://ncbi.nlm.nih.gov/pubmed/18086860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071155
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