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Kinetic control of dimer structure formation in amyloid fibrillogenesis

Amyloid fibril formation involves nonfibrillar oligomeric intermediates, which are important as possible cytotoxic species in neurodegenerative diseases. However, their transient nature and polydispersity have made it difficult to identify their formation mechanism or structure. We have investigated...

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Detalhes bibliográficos
Main Authors: Hwang, Wonmuk, Zhang, Shuguang, Kamm, Roger D., Karplus, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516495/
https://ncbi.nlm.nih.gov/pubmed/15326301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402634101
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