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Kinetic control of dimer structure formation in amyloid fibrillogenesis

Amyloid fibril formation involves nonfibrillar oligomeric intermediates, which are important as possible cytotoxic species in neurodegenerative diseases. However, their transient nature and polydispersity have made it difficult to identify their formation mechanism or structure. We have investigated...

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Autores principales: Hwang, Wonmuk, Zhang, Shuguang, Kamm, Roger D., Karplus, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC516495/
https://ncbi.nlm.nih.gov/pubmed/15326301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402634101
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