PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

Inadequate compensatory β cell hyperplasia in insulin-resistant states triggers the development of overt diabetes. The mechanisms that underlie this crucial adaptive response are not fully defined. Here we show that the compensatory islet-growth response to insulin resistance in 2 models — insulin r...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kulkarni, Rohit N., Jhala, Ulupi S., Winnay, Jonathon N., Krajewski, Stan, Montminy, Marc, Kahn, C. Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516265/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15372107/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI21845
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