Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Insulin receptor substrate–1 (IRS-1) is pivotal in mediating the actions of insulin and growth factors in most tissues of the body, but its role in insulin-producing β islet cells is unclear. Freshly isolated islets from IRS-1 knockout mice and SV40-transformed IRS-1–deficient β-cell lines exhibit m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Kulkarni, Rohit N., Winnay, Jonathon N., Daniels, Molly, Brüning, Jens C., Flier, Sarah N., Hanahan, Douglas, Kahn, C. Ronald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 1999
Gaiak:
Rapid Publication
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409887/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8339
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