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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
Inadequate compensatory β cell hyperplasia in insulin-resistant states triggers the development of overt diabetes. The mechanisms that underlie this crucial adaptive response are not fully defined. Here we show that the compensatory islet-growth response to insulin resistance in 2 models — insulin r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516265/ https://ncbi.nlm.nih.gov/pubmed/15372107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421845 |
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